Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies
نویسندگان
چکیده
منابع مشابه
Pediatric Inflammatory Bowel Disease with Cytoplasmic Staining of Antineutrophil Cytoplasmic Antibodies
BACKGROUND It is unusual for the antineutrophil cytoplasmic antibody with cytoplasmic pattern (cANCA) to present in patients with inflammatory bowel disease (IBD) without vasculitis. The purpose of this study was to describe the occurrence and characteristics of pediatrics IBD with cANCA. METHODS A retrospective review of pediatric IBD associated with cANCA serology in patients from King Abdu...
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Background and aims: Several antibodies have been reported in the sera of patients with Crohn’s disease (CD) and ulcerative colitis (UC). The most commonly described are anti-Saccharomyces cerevisiae mannan antibodies (ASCA) in CD and perinuclear antineutrophil cytoplasm antibodies (pANCA) in UC. Familial clustering of these antibodies has been described, suggesting they might be genetic marker...
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متن کاملAntineutrophil cytoplasmic antibodies.
Antineutrophil cytoplasmic antibodies (ANCA) are predominantly IgG autoantibodies directed against constituents of primary granules of neutrophils and monocytes lysosomes. Although several antigenic targets have been identified, those ANCA directed to proteinase 3 or myeloperoxidase are clinically relevant, whereas the importance of other ANCA remains unknown. Both are strongly associated with ...
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ژورنال
عنوان ژورنال: Clinical and Developmental Immunology
سال: 2013
ISSN: 1740-2522,1740-2530
DOI: 10.1155/2013/196012